The finalists in the women’s draw will be decided on Thursday in two intriguing ties on Arthur Ashe.
The first match sees Australian Open champion Aryna Sabalenka, the No 2 seed, face first-time grand slam semi-finalist Emma Navarro.
Sabalenka has reached at least the quarter-final stage of the last eight grand slams she has played in and is in the last four of the US Open for the fourth year in a row.
In the second semi-final, Karolina Muchova will take on American sixth seed Jessica Pegula.
Pegula stunned world No 1 Iga Swiatek 6-2, 6-4 late on Wednesday night in New York after Muchova had beaten Beatriz Haddad Maia 6-1 6-4.
Great Britain’s Jack Draper is into the men’s semi-finals, on Friday night, after his win over Alex de Minaur. He will face world No 1 Jannik Sinner. Taylor Fritz and Frances Tiafoe meet in the other semi-final.
Today’s order of play at the US Open
Arthur Ashe Stadium
8pm BST start (3pm ET)
Midnight BST (7pm ET)
How to watch the US Open on TV and streaming in the UK
Sky Sports has the broadcasting rights to show the US Open live from Flushing Meadows.
Gigi Salmon is presenting the coverage alongside the likes of Tim Henman, Laura Robson, Martina Navratilova, Marion Bartoli, Karthi Gnanasegaram, Feliciano Lopez, Naomi Cavaday and Jonathan Overend.
How to watch the US Open on TV in the US
ESPN have the broadcasting rights to show the tournament.
When does the US Open start and end?
The US Open started on Monday, August 26, and finishes on Sunday, September 8.
When do the US Open finals take place?
The women’s final takes place on September 7 at 9pm. The men’s final is the following day, at 7pm.
Where is the US Open held?
The home of the US Open is the Billie Jean King National Tennis Center in Flushing Meadows, New York.
What is the US Open prize money?
The US Open total prize pool is $75 million (£58.3m), up 15 per cent on 2023.
The men’s and women’s singles champions will each take home £2.8m and the runners-up will earn £1.4m.
Prize money for progression through the earlier rounds is as follows: first round (£77,813); second round (£108,937); third round (£167,296); round of 16 (£252,890); quarter-finals (£412,405); semi-finals (£778,123).
What happened to Emma Raducanu?
Emma Raducanu was knocked out by Sofia Kenin in a 6-1, 3-6, 6-4 first-round defeat on the Grandstand court.
It looked like it could be a short outing as Kenin rattled through the first set, but Raducanu made a match of it by sending it to three sets.
A poor service game midway through the decider proved costly as the former champion headed home.
Having played just one tournament since Wimbledon and skipping the Olympics to focus on her preparation for the US Open, she will be desperately disappointed to fall at the first hurdle and questions remain over the direction of her career.
Which British players are in the draw and when do they play?
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Jack Draper beat Alex de Minaur in the quarter-finals on Wednesday
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Daniel Evans lost to Alex de Minaur in the third round on Saturday, August 31
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Katie Boulter lost to Jessica Bouzas Maneiro on Thursday, August 29
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Harriet Dart lost to Marta Kostyuk in the second round on Wednesday, August 28
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Emma Raducanu lost to Sofia Kenin on Tuesday, August 27
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Jan Choinski lost to Roberto Carbelles Baena in the first round on Monday, August 26
Who are the defending US Open champions?
Last year, Novak Djokovic equalled Margaret Court’s record of 24 major titles with a brilliant performance over Daniil Medvedev. But the defending champion’s quest for a 25th grand slam singles title was ended on Saturday night by Australia’s Alexei Popyrin.
In the women’s final, Coco Gauff stormed back from a set down to beat Aryna Sabalenka and claim her first grand slam title but was thwarted this year in the fourth round by her compatriot Emma Navarro.
Latest odds
Men’s winner
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Jannik Sinner 4/9
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Taylor Fritz 9/2
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Jack Draper 9/1
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Frances Tiafoe 14/1
Women’s winner
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Aryna Sabalenka 4/6
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Karolina Muchova 11/2
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Jessica Pegula 11/4
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Emma Navarro 10/1